In collaboration with the Biomedical Institute at UCPH we investigate how G-protein-coupled receptors (GPCRs) (a major family of cell-surface receptors) respond to mechanical forces. This includes advanced techniques to manipulate and measure forces at the single-molecule level, providing insight into signaling mechanisms. Our research contributes to a deeper understanding of how cells sense and respond to their mechanical environment.

By using optical tweezers or other mechanical tools on cells we apply local or global mechanical stresses to the cells. The biochemical response is monitored using miniGs which bind to GPCRs upon activation.

This work is part of an interdisciplinary consortium called GPCRmec, funded by the Novo Nordisk Foundation, with multiple academic partners.

Holmkvist, J.F.L. et.al. Direct tensile force activates Adgrl3 in a tethered agonist-dependent manner.

BioRxiv: https://doi.org/10.64898/2026.02.27.706744 (2026).