In collaboration with Jesper Nylandsted at the Danish Research Center we have investigated how cells repair surface lesions by recruiting different types of annexins. We have locally punctures living cells while monitoring recruitment of fluorescent annexins to the site of damage. To gain biophysical insight into the mechanism of annexins we have made in vitro studies using membrane vesicles with encapsulated annexins. these vesicles were optically shape modulated or punctures to understand the reaction of annexins to shape and to formation  membrane holes.

Thermoplasmonics is currently being used to study the repair mechanisms of nuclear membranes as well.

• JOVE (2024), Danielsen et al.
• Nanoscale (2022), Moreno-Pescador et al.
• Soft Matter (2021), Florentsen et al.
• J. of Biological Chemistry (2021), Heitmann et al.
• Cells (2020), Bendix et al.